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Lower incisional hernias extend into thepelvis and the visceral sac holds the lower aspect of the mesh in place with the patient inthe upright position; only a retropubic suture secures the lower aspect of the mesh (C).(Adapted with permission from: Wantz GE. The high costof animal toxicity testing and large number of chemicals yetto be tested make these methods valuable tools for predictinghazard

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